| 1 | This page will document a biological compound sensor being |
| 2 | developed for the research group of Profs. Mohanty and Eramilli. |
| 3 | |
| 4 | This device will use a proprietary sensor chip to measure the |
| 5 | concentrations of various biological compounds in an aqueous solution. |
| 6 | |
| 7 | == Open Issues == |
| 8 | |
| 9 | * Mechanics - connector type and pinout for cell connection |
| 10 | * See [http://joule.bu.edu/~hazen/BioSensor/multisideshow.pdf CAD drawing] |
| 11 | proposed 8-device prototype. What are the units? |
| 12 | |
| 13 | == Prototype 1 Specifications == |
| 14 | |
| 15 | * Generate a fixed AC stimulus signal of 10mV at 17Hz (sinusoidal) |
| 16 | * Provide a DC bias for ''''V(DS)''' on which AC stimulus is superimposed |
| 17 | with a range of -2V to +2V. Set in 5mV or smaller steps, |
| 18 | absolute precision to 1mV desirable. |
| 19 | * Provide an analog switch to route the above ''''V(DS)''' combined |
| 20 | AC/DC signal to one of eight electrodes. |
| 21 | * Output a separate DC source for ''''V(GS)''' with same |
| 22 | specs as for ''''V(DS)''' above. This will set the potential of |
| 23 | an electrode immersed in the solution. |
| 24 | * Provide two additional side-gate bias voltages with an output |
| 25 | range of -5 to +5V (Precision? Step size?) |
| 26 | * Provide eight analog switches for each side-gate bias voltage |
| 27 | to route the above signals to the desired device. |
| 28 | * Measure the DC and AC currents through the sensor. The AC current will |
| 29 | be measured using a phase-sensitive detector, converted to a DC signal, |
| 30 | and digitized with an ADC. |
| 31 | |
| 32 | Future versions may also have |
| 33 | variable frequency and amplitude for the AC stimulus. |
| 34 | |
| 35 | == Analog Circuit Implementation == |
| 36 | |
| 37 | The analog interface electronics will be implemented on a custom PC board |
| 38 | which will have a connector on which the sensor cell can plug directly. |
| 39 | |
| 40 | Please refer to the |
| 41 | [http://joule.bu.edu/~hazen/BioSensor/proto_block.pdf block diagram] |
| 42 | The blue lines show the wiring on the device itself, or it''s mounting PC board. |
| 43 | The blue squares represent connection points to the electronics. |
| 44 | |
| 45 | Four DC bias voltages are buffered and driven to the device as shown. Three analog switches |
| 46 | for each of 8 devices allow bias signals to be selectively applied to one device at a time. |
| 47 | |
| 48 | Readout is via a current-sensitive op-amp circuit, a phase-sensitive detector, DC |
| 49 | amplifier and ADC. |
| 50 | |
| 51 | == Control and Interface == |
| 52 | |
| 53 | We currently plan to purchase an off-the-shelf embedded controller |
| 54 | and A/D interface board. See links below for some likely options. |
| 55 | We would provide software on the embedded computer to support |
| 56 | setting the analog switches and bias voltages, and measuring |
| 57 | the current with an ADC. |
| 58 | |
| 59 | A simple TCP/IP server or USB equivalent would be provided, |
| 60 | with a very simple DEMO program running on a PC to show |
| 61 | functionality. |
| 62 | |
| 63 | * [http://www.embeddedarm.com/products/board-detail.php?product=TS-7260 TS-7260] |
| 64 | from technologic systems looks like a good bet. |
| 65 | * [http://www.embeddedarm.com/products/board-detail.php?product=TS-ADC16 TS-ADC16] |
| 66 | board would provide DAC (12-bit) and ADC (16-bit) and digital I/O functions – |
| 67 | [http://joule.bu.edu/~hazen/BioSensor/TS-ADC16%20FPGA%20registers-v2.pdf preliminary manual] |
| 68 | * [http://www.embeddedarm.com/products/board-detail.php?product=TS-9700 TS-9700] |
| 69 | alternative I/O board with 12-bit DAC/ADC functions. |
| 70 | |
| 71 | |
| 72 | |